The FDA has approved weekly Semaglutide injections for chronic weight management in obese or overweight adults with at least one weight-related condition. This under-the-skin injection can help you lose up to two pounds per week when paired with a reduced-calorie diet and increased physical activity.

What is Semaglutide?

Semaglutide is an FDA-approved weight loss injection. By mimicking a hormone in the body, Semaglutide increases insulin secretion while slowing down how fast your stomach empties food. This suppresses your appetite, so you feel full longer, helping you eat less and lose weight.


The drug was approved in 2017 at a lower dose to help control blood sugar in Type 2 diabetes. People taking Semaglutide for blood sugar control lose weight as an additional benefit. After studying a higher amount of the medication in people without Type 2 diabetes, the FDA approved Semaglutide for weight loss in qualified adults.

How does Semaglutide work for weight loss?

Semaglutide mimics a hormone called glucagon-like peptide-1 (or GLP-1) that targets areas in the brain that regulate appetite and food intake. Your digestive tract releases this incretin hormone after you have eaten a meal, lowering your blood sugar by triggering insulin release to block sugar production. Doing so helps you eat less and lose one to two pounds per week. Semaglutide should be combined with lifestyle changes, including a healthy diet and exercise. 

Learn How to Inject Weight Loss Medication
Semaglutide Weight Loss Injections

What are the benefits of Semaglutide weight loss injections?

  • Lower blood sugar without any increase in hypoglycemia.
  • Reduced body weight, lipids, blood pressure, inflammatory markers, and oxidative stress.
  • Suppressed appetite.
  • Enhanced insulin synthesis and secretion.
  • Reduced glucagon levels in fasting and after eating.
  • A promoted sensation of fullness in the brain.
  • More significant improvement in cardiovascular risk factors associated with obesity

Are there any side effects?

It is essential to be aware of reported side effects when determining whether Semaglutide weight loss injections suit your weight loss journey.


The most common side effects include the following:

  • Nausea
  • Diarrhea
  • Vomiting
  • Constipation
  • Stomach pain
  • Headache
  • Fatigue
  • Indigestion
  • Dizziness
  • Bloating
  • Burping

Semaglutide FAQs

  • How much weight loss can be expected from Semaglutide, and do you still have to diet while taking it?

    Patients typically experience an average weight loss of 1-4 pounds per week, with some achieving even greater results. Dietary modifications are essential for effective weight management and the maintenance of a healthy lifestyle. We highly advocate for the adoption of a low-carbohydrate or ketogenic diet for sustained success.

  • What is the recommended duration for the administration of Semaglutide and how often should I administer the injection?

    In the event of consistent weight loss progress, it is recommended to persist until reaching your desired goal. It is recommended to establish a specific day and time each week and stick to this schedule.

  • I have never had an injection before; how do I do it and does it hurt?

    Please visit the Texas Weight Loss YouTube channel for an instructional video providing detailed guidance on the administration of a Semaglutide injection. The majority of patients report minimal to no discomfort as we utilize a smaller needle and deliver the medication into the adipose tissue rather than the muscle.

  • Is Semaglutide expensive?

    Texas Weight Loss offers patients access to an in-house Semaglutide sourced from a 503b compounding pharmacy, guaranteeing quality control while providing a cost-effective alternative to high-priced brand-name medications.

  • Is it safe to take Semaglutide in combination with Phentermine?

    Yes, Phentermine and Semaglutide can be taken together, but it's essential to proceed under strict medical supervision.